MonoPure Curcumin EC (30 ct)

Take one softgel twice per day, or as directed by your healthcare practitioner.

Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged.

Wheat, gluten, corn, yeast, soy protein, dairy products, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Omega MonoPure® Curcumin EC features highly absorbable, patented forms of
both monoglyceride fish oil and standardized turmeric extract to offer combined
support for cellular health and the modulation of cytokine production.*
The two most well-researched omega-3 fatty acids are eicosapentaenoic acid
(EPA) and docosahexaenoic acid (DHA). EPA plays a role in supporting healthy
cardiac and circulatory systems while DHA is an essential structural component
of the central nervous system. In addition to other physiological effects, research
has established that omega-3 fatty acids antagonize arachidonic acid-induced
eicosanoid formation. They also help generate resolvins and protectins (EPA and
DHA metabolites, called specialized proresolving mediators (SPMs), that are
naturally produced in vivo through enzymatic conversion of EPA and DHA) to aid
the body’s “cleanup” response to the arachidonic acid cascade, and they promote
cardiovascular health.*[1-7]
Curcumin, the principal curcuminoid in turmeric, has been the subject of vast
research in recent years. The pleiotropic nature of curcumin’s biological effects
makes it an interesting compound to researchers who study common chronic
health concerns, such as those associated with joints, the cardiovascular system,
glucose metabolism, brain function, mood, and cell-cycle regulation. These effects
make curcumin applicable to a wide array of clinical presentations.*[8-13]
MaxSimil® Fish Oil Concentrate
MaxSimil is a novel monoglyceride concentrated fish oil developed using patented
lipid absorption enhancement technology (PLATform), a unique vehicle by which
to deliver EPA and DHA. Due to the fact that monoglyceride oils are intrinsically
emulsifiers and are, by nature, in a readily absorbable form, they can bypass the
body’s normal fat digestion process. Studies conducted by the manufacturer of
MaxSimil provide promising results that show MaxSimil fish oil may be better
absorbed than other fish oils. Rather than supplying a single molecule or metabolite,
which would mirror the pharmaceutical model, MaxSimil provides all the benefits
of EPA and DHA as well as the expected and desirable benefits of their metabolites.
From a quality perspective, every batch of fish oil is IFOS five-star certified to ensure
the highest standards for purity, potency, and freshness. The fish oil is also non-
GMO, certified sustainable from Scandinavia, and antibiotic-free.*[14-16]
An unpublished single dose, double-blind, crossover, pharmacokinetic study
was performed in healthy overnight fasted male and female subjects (n = 20)
aged between 19 and 60 years. Each participant was administered six softgels
(containing 2000 mg EPA and 1500 mg DHA) of ethyl ester (EE) fish oil or MaxSimil.
Parameters studied were plasma EPA and DHA concentration (as percent of total
fatty acids), maximum concentration (Cmax), time to concentration (Tmax) and
area under the curve (AUC). The results indicated that at peak concentration, the
MaxSimil EPA and DHA were three times higher, reached maximum concentration
faster, and maintained plasma levels longer than the EE EPA+DHA demonstrating
enhanced bioavailability of the MaxSimil form.[16] While there is no conclusive
published evidence at this time, the results from studies conducted by the makers
of MaxSimil provide a promising indication of enhanced absorption rates, and
additional peer-reviewed research is warranted.*
In a placebo-controlled, study in healthy volunteers (n = 21) investigators examined
the effect of omega-3 fatty acid (2.4g/day) supplementation on increasing
biologically active SPMs over a seven-day period. After five days, concentrations of
SPMs were effectively increased.[7] This study and others contribute to the body of
research supporting a role for omega-3 supplementation and may help explain their
role in cardiovascular health.*[2,3,6,7]
BCM-95® (Turmeric Extract)
While the beneficial effects of curcumin are hardly arguable, an area of intense
research in recent years has been how to make curcumin more bioavailable.
Poor absorption in the gastrointestinal (GI) tract, rapid metabolism, and rapid
systemic elimination are typically characteristic of commercially available
curcumin preparations. During the course of investigating a way to overcome these
challenges, scientists discovered they could take advantage of the synergism
between the curcuminoids and the sesquiterpenoids (essential oils) naturally
present in turmeric.[8] This discovery resulted in the development of BCM-95®—a
100% natural whole turmeric extract composed of curcuminoids (curcumin,
demethoxycurcuminoid, and bisdemethoxycurcuminoid) and essential oils.*
In a pilot crossover study, Antony et al compared the bioavailability of three forms
of curcumin: BCM-95, normal curcumin, and a non-controlled release curcumin-
piperine-lecithin formula. The data demonstrated that the absorption of curcumin
from BCM-95 was fast, it peaked at 4.5 hours with a gradual decline, and curcumin
was still detectable in the blood at eight hours. The other formulas showed slower
curcumin absorption with an earlier peak and rapid disappearance from the blood
after 4.5 hours. The relative bioavailability of BCM-95 was approximately 6.93-fold
higher than normal curcumin and 6.3-fold higher than the non-controlled release
curcumin-lecithin-piperine formula. According to the researchers, the results of
this study indicated that the BCM-95 curcumin was “absorbed early and retained
longer” compared to other forms.*[8]
The safety and efficacy of curcumin has been demonstrated in numerous animal,
preclinical, and human studies. The mechanisms have not been fully elucidated, but
it is known that curcumin has powerful antioxidant activity and that it has multiple
molecular targets, including transcription factors, cell cycle proteins, cytokines,
chemokines, enzymes (e.g., COX-2), receptors, and adhesion molecules.*